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This introductory textbook chapter presents data demonstrating decreased global biodiversity and its link to human activity. The resource includes a field-based student investigation of local biodiversity, links to current news articles, and an essay-based unit assessment. A teacher's guide supports classroom use. This is chapter 1 in the unit, Losing Biodiversity, is about the endangerment and extinction of entire species of plants and animals throughout the world due to human actions. The resource is part of Global System Science (GSS), an interdisciplinary course for high school students that emphasizes how scientists from a wide variety of fields work together to understand significant problems of global impact.